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Acalabrutinib solubility decreases with increasing gastric pH The prescription strength tablet formulation is available in 20 mg and 40 mg tablets, and your prescribed dose will be based on the illness being treated. PEPCID may be taken with or without food [see Clinical Pharmacology (12. Relax knowing you have Maximum Strength PEPCID AC ® on your side all day or all night† as it works fast to relieve heartburn and is strong enough to prevent heartburn. It starts to relieve heartburn in 15–30 minutes, and controls acid all day or all night. Applies only to oral form of both agents. The recommended adult oral starting dose for pathological hypersecretory conditions is 20 mg q 6 h. The maximum daily dose of over-the-counter (OTC) famotidine (Pepcid AC, Zantac 360) in adults and children over 12 years of age is 40 mg per day unless your doctor prescribes it otherwise. Pepcid AC, Zantac 360 (famotidine) dosing, indications, interactions, adverse effects, and more acalabrutinib Monitor Closely (1)famotidine decreases levels of acalabrutinib by increasing gastric pH. Duration of therapy: 4 weeks Original Strength PEPCID AC ® and Maximum Strength PEPCID AC ® are H2 blockers, and start to work within 15-30 minutes and controls acid all day or all night. Since 20 mg or 40 mg tablet strength cannot be used for this dosage regimen, use an alternate famotidine formulation. Overview From the #1 doctor recommended acid reducer brand, Maximum Strength PEPCID AC ® tablets with famotidine work before, during, or after the start of heartburn symptoms. Modify Therapy/Monitor Closely. Use another famotidine formulation for pediatric patients weighing less than 40 kg. 16 YEARS AND OLDER: Oral: Usual dose: 40 mg orally once a day at bedtime OR 20 mg orally 2 times a day. The use of PEPCID 20 mg and 40 mg tablets is not recommended in pediatric patients weighing less than 40 kg because the lowest available strength (20 mg) exceeds the recommended dose for these patients. Maintenance dose: 20 mg orally once a day at bedtime. 25 mg/kg IV injected over at least 2 minutes OR infused over 15 minutes every 12 hours. In general, high doses are used short term (generally four to eight weeks) for active conditions, while lower doses may be used for a longer period of time The dosage of PEPCID in patients with pathological hypersecretory conditions varies with the individual patient. If your symptoms persist more than 2 weeks, contact your doctor From the #1 doctor recommended acid reducer brand, Original Strength PEPCID AC ® is a famotidine tablet that works fast and lasts to prevent and relieve occasional heartburn. In some patients, a higher starting dose may be required Initial dose: 0. * *Based on 9-hour acid control studies during the day and 12-hour acid control studies during the night. 3 Administration Instructions Take PEPCID once daily before bedtime or twice daily in the morning and before bedtime, as recommended. Acid control does not imply symptom relief.