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It is the first preferred medicine effectively used in people with type II diabetes (a condition where your body cannot produce sufficient insulin or resists insulin). In fact, many new combination drugs are often created with metformin as one of the main ingredients Metformin is a first-line drug in the treatment of overweight and obese type 2 diabetic patients, offering a selective pathophysiological approach by its effect on insulin resistance. Metformin is a medicine used together with diet to lower high blood sugar levels in patients with type 2 diabetes. It belongs to a class of medications called Biguanide. Find out how metformin treats type 2 diabetes, gestational diabetes and polycystic ovary syndrome, and how to take it. And while the FDA has not yet approved its use as a therapeutic drug for longevity, it could actually happen -Metformin, if not contraindicated, is the preferred initial pharmacologic agent for treatment of type 2 diabetes mellitus. 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