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[8] [20] It is on the World Health Organization's List of Essential Medicines. Metformin was discovered in 1922. Officinaliswas found to be rich in guanidine, a substance with blood glucose-lowering activity that formed the chemical basis of metformin. Hazelwood, MO 63042 Contact Details. Is made in several countries, including the U. Metformin is an oral antidiabetic drug for the treatment of diabetes and created by Bristol-Myers Squibb Company. Metformin hydrochloride is the scientific or generic name for the active ingredient in tablets sold in Australia under 40 different proprietary or brand names. But it was not approved by the FDA in the United States until 1994.. Click here to read our Diabetes and Metformin FAQs including information on lactic acidosis. Metformin is approved in the US and the UK as a treatment for type 2 diabetes and contains the active ingredient metformin hydrochloride (or metformin hcl) So after languishing during the Great Depression and World War II, the French finally developed Galegine, or metformin, for clinical use in 1957. This article traces the roots of the antihyperglycaemic biguanide metformin from the use of Galega officinalis(goat’s rue or French lilac) as a herbal treatment for the symptoms of diabetes. History Metformin was originally developed from natural compounds found in the plant Galega officinalis, known as French lilac or goat’s rue Created by Bristol-Myers Squibb Company, Metformin is approved in the US and the UK as a treatment for type 2 diabetes. [19] It was introduced as a medication in France in 1957 and the United States in 1995. It was approved the following year in the United Kingdom, and made its way to Canada in 1972. [4] It works by decreasing glucose production by the liver and increasing the insulin sensitivity of body tissues. We found the packaging of that particular version. [4] [11] Metformin is in the biguanide class. [12] French physician Jean Sterne began study in humans in the 1950s. Other Names for Metformin Metformin is sold both under brand names, and also as a generic drug 1 Answer - Posted in: metformin - Answer: Mallinckrodt Inc. [4] Metformin was discovered in 1922. [19] French physician Jean Sterne began the study in humans in the 1950s. The metformin recall noted in this post is specific to two lots in Kansas City, Missouri, the location of Nostrum Laboratories, Inc.